仙林校区现代生物研究院BO-403
qian.xiao@nju.edu.cn
工作经历
2025- 南京大学医药院附属鼓楼医院 双聘研究员
2024- 南京大学医药生物技术国家重点实验室 至诚青年教授，研究员
2023- 南京大学现代生物研究院 至诚青年教授，研究员
2021-2023 美国罗格斯大学新泽西肿瘤研究所 助理教授
2016-2021 美国耶鲁大学医学院 研究科学家，副研究员
荣誉奖励
2023年国家级高层次青年人才项目入选者
学术任职
2024-2027 江苏省免疫学会皮肤免疫专业委员会委员
2026 《Frontiers in Immunology》Guest Editor
2021 《Frontiers in Cell and Developmental Biology》Guest Editor
2025- 《ACTA BIOCHIMICA ET BIOPHYSICA SINICA (ABBS)》Youth Editor
2025- 《The Innovation》Youth Editor
2021- 《Technology in Cancer Research & Treatment (TCRT)》Associate Editor
代表性成果
专著章节:
Q Xiao, and X Su*. Imaging CAR-T synapse as a quality control for CAR engineering. Methods in Molecular Biology series volume Immune Synapse Methods II. 2023 2654:503-512.
研究论文：
1. X Zhang, Q Xiao, L Zeng, F Hashmi, K Sato, T. M. P. Hartwich, M Mansolf, Y Y-Hartwich, X Su*. IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers. Nature Chemical Biology. 2026 Mar;22(3):379-391.
2. C Mattivi, S Wang, L Ji, Q Xiao*, J Cao*. HLA-Knockout: Enabling Allele-Specific Knockout of HLA Class I Genes for Immunogenic Engineering. HLA. 2026 Jan;107(1):e70548.
3. Q Xiao, X Zhang, L Tu, J Cao, C. S. Hinrichs, and X Su*. Size-dependent activation of chimeric antigen receptor. Science Immunology. 2022 Aug 5;7(74):eabl3995.
4. Q Xiao, J Wu, W Wang, S Chen, Y Zheng, X Yu, K Meeth, M Sahraei, A. LM Bothwell, L Chen, M Bosenberg, J Chen, V Sexl, L Sun, L Li, W Tang, and D Wu*. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation. Nature Medicine. 2018 Mar;24(3):262-270.
5. R Zhao#, Q Xiao#, M Li, W Ren, C Xia, X Liu, Y Li, Z Wang, T Tan, D Wu, L Sun*. Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy. Antibody Therapeutics. 2020 Apr;3(2):63-70. (#equal contribution)
6. J Hu, Z Wang, Z Chen, A Li, J Sun, M Zheng, J Wu, T Shen, J Qiao, L Li, B Li, D Wu, and Q Xiao*. DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer. Biomedicine & Pharmacotherapy. 2020 Jul;127:110229.
7. T Shen, Z Chen, J Qiao, X Sun and Q Xiao*. Neutralizing monoclonal antibody against Dickkopf2 impairs lung cancer progression via activating NK cells. Cell Death Discovery. 2019 Jul 31;5:123.
综述论文：
1. X Tang, Q Xiao*. CAR-macrophages: a new chapter in cancer immunotherapy. Acta Biochim Biophys Sin (Shanghai). 2026 Feb 11. doi: 10.3724/abbs.2026017. Online ahead of print.
2. X Hu, Z Chen, Z Wang, and Q Xiao*. Cancer evolution: Special focus on the immune aspect of cancer. Seminars in Cancer Biology. 2022 May 16;86(Pt 2):420-435.
3. Q Xiao, C. K. McAtee, X Su*. Phase separation in immune signaling. Nature Reviews Immunology. 2022 Mar;22(3):188-199.
4. Z Chen, Y Tang, and Q Xiao*. The involvement of noncanonical Wnt signaling in cancers. Biomedicine & Pharmacotherapy. 2021 Jan;133:110946.