2021-2023，哈佛大学医学院讲师

2023-2024，哈佛大学医学院助理教授

2024-    ，南京大学现代生物研究院研究员

国家级青年人才项目入选者

江苏省特聘教授

NIH K99/R00 Pathway to Independence Award

1. Yan, P., Bu, X., Hou, T., Chen, L., Zhong, G., Huang, D., Wang, J., Qi, Y., Jiang, W., Li, Z., Xue, X., Gao, Y., Liu, J., Inuzuka, H., Freeman, G. J. †, Wei, W. †, & Dai, X†. (2026). CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy. Journal for immunotherapy of cancer, 14(1), e013498. 

2. Dai X*, Jiang C*, Jiang Q*, Fang L, Yu H, Guo J, Yan P, Chi F, Zhang T, Inuzuka H, Asara JM, Wang P, Guo J†, Wei W†. AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. Nature Metabolism. 2023 Feb 2. doi: 10.1038/s42255-022-00732-4. PMID: 36732624. 

3. Dai X*, Bu X*, Gao Y*, Guo J, Hu J, Jiang J, Zhang Z, Xu K, Duan J, He S, Zhang J, Wan L, Liu T, Zhou X, Hung M-C, Freeman G†, Wei W.† (2021) Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Molecular Cell. 2021 Apr 21:S1097-2765(21)00232-X. doi: 10.1016/j.molcel.2021.03.037. PMID: 33909988.

4. Dai X†, Wei W†. Lactate fuels mitosis. Molecular Cell. 2023 05 18; 83(10):1549-1551. PMID: 37207623; PMCID: PMC10809221.

5. Gan W*, Dai X*, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. (2020) LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nature Cell Biology 22: 246-256. PMID: 32015438. PMCID: PMC7076906. 

6. Dai X*, Liu H*, Shen S, Guo X, Yan H, Ji X, Li L, Huang J, Feng XH, Zhao B (2015) YAP activates the Hippo pathway in a negative feedback loop. Cell research 25: 1175-8. PMID: 26315483. PMCID: PMC4650621.

7. Jiang C*, Dai X*, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J†, Wei W†. Ring domains are essential for GATOR2-dependent mTORC1 activation. Molecular Cell. 2023 Jan 5;83(1):74-89.e9. doi: 10.1016/j.molcel.2022.11.021. Epub 2022 Dec 16. PMID: 36528027. 

8. Dai X†, Yan P, Wei W†. Amino acid availability governs mTOR ubiquitination. Cell Research. 2023 Dec 15. PMID: 38102197.

9. Dai X*, Liu J*, Wei W. Mitochondrial PD-L1 modulates cancer immunotherapy. Cell Research. 2023 Jan 24. doi: 10.1038/s41422-023-00777-4. PMID: 36693901.

10. Jiang Q*, Zhang X*, Dai X*, Han S, Wu X, Zhang N, Wang L, Wei W, Xie W, Guo J. (2022) S6K1 mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions. Nature Communications. 2022 Mar 22;13(1):1548. doi: 10.1038/s41467-022-28910-8. PMID: 35318320; PMCID: PMC8941131.

11. Liu L*, Dai X*, Yin S, Liu P, Wei W†, Gan W†. (2022) The DNA-PK/mTORC2/ECT2 pathway promotes AKT activation in response to DNA damage. Science Signaling 2022 Jan 4;15(715):eabh2290. doi: 10.1126/scisignal.abh2290. Epub 2022 Jan 4. PMID: 34982576; PMCID: PMC8992387.

12. Liu H*, Dai X*, Cao X*, Yan H, Ji X, Zhang H, Shen S, Si Y, Zhang H, Chen J, Li L, Zhao JC, Yu J, Feng XH, Zhao B (2018) PRDM4 mediates YAP‐induced cell invasion by activating leukocyte‐specific integrin β2 expression. EMBO reports: e45180. PMID: 29669796. PMCID: PMC5989780  

13. Dai X*, GaoY*, Wei W. (2021) Post-translational regulations of PD-L1/PD-1: Mechanisms and opportunities for combined immunotherapy. Seminars in Cancer Biology. 2021 Apr 5:S1044-579X(21)00103-6. doi: 10.1016/j.semcancer.2021.04.002. PMID: 33831533. 

14. Dai X*, Liu J*, Wei W. (2020) DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma. Protein Cell. PMID: 32323143. 

15. Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, Lee YR, Pan L, Shaw RJ, Yuan J, Wei W. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science. 2023 06 30; 380(6652):1372-1380. PMID: 37384704; PMCID: PMC10617018.