工作经历
2015.07—2018.08 南京大学医学院，基础医学，助理研究员
2018.09—至 今南京大学医学院，基础医学，副教授，硕士生导师
2025.09—至今南京大学医学院，发展办公室，主任
荣誉奖励
全国高校青年教师教学竞赛一等奖，2020
全国高校（医学类）微课教学比赛三等奖，2020
第三届全国仿真创新应用大赛三等奖，2024
高等学校医药类虚拟仿真实验教学项目作品展示三等奖，2022
第六届全国大学生基础医学创新研究论坛二等奖（指导老师），2020
江苏省五一劳动奖章，2020
江苏省本科高校青年教师教学竞赛特等奖，2020
江苏省技术能手称号，2020
江苏省五一创新能手荣誉称号，2020
江苏省青年岗位能手称号，2021
南京大学南雍青年教学名师，2026
南京大学育教融合奖，2025
南京大学中国银行青年教师优秀教学奖，2024
南京大学卓越教师发展奖，2023
南京大学郑钢基金——学业导师优秀示范奖，2023
南京大学研究生招生先进个人，2023
南京大学中国银行教师教学成果奖，2021
南京大学郑钢基金——学业导师优秀示范奖，2021
南京大学档案工作先进个人（年鉴类），2021
南京大学魅力导师奖，2021
《南京大学年鉴 2020》优秀撰稿人，2020
“新华报业”南京大学优秀青年教师奖，2018
南京大学医学院优秀教师奖，2025
南京大学医学院优秀教师奖，2021
南京大学医学院优秀教师奖，2018
学术任职
2023.05—至今 南京大学科学与技术伦理委员会医学伦理分委会委员
2021.05—至今 第二届中国研究型医院学会麻醉学专业委员会委员
2020.11—至今 江苏省病理生理学会常务理事
2019.12-2022.12中国神经科学学会麻醉与脑功能分会青年委员会委员
2018.11—至今 江苏省高等学校医药教育研究会常务理事
代表性成果
[1] Han, X., Zhu, S., Zhang, H., Xia, T.,* & Gu, X. (2026). Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers Predicting Neuropsychiatric Symptom Progression in Mild Cognitive Impairment and Alzheimer's Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 40(2), e71447.
[2] Liu, C., Wang, Y., Xia, T.,# Lin, J., Liao, Q., Li, Y., Zhang, Y., Miao, C., Yi, X., Sun, L., Ma, Z., Cheng, X., Jiang, B., Tian, F., Ju, Z., Liu, B., Kong, W., Fu, Y., Yang, Z., Liu, J., … Wang, W. (2026). HuR coordinates systemic aging through platelet infiltration. Nature communications, 10.1038/s41467-026-72481-x. Advance online publication.
[3]Ye, C., Qian, Y., Chen, C., Huang, Y., Liu, B., Peng, L., Ma, Z., Gu, X., & Xia, T.* (2026). Cullin-1 silencing ameliorates isoflurane-induced cognitive impairment via inhibition of PHLPP1 degradation in adult mice. Experimental neurology, 396, 115505.
[4] Zheng, Z., Chen, C., Zhu, S., Zhu, X., Tu, H., Ding, X., Xia, T.,* & Gu, X. (2026). TERT activator compound alleviates cigarette smoke-induced cognitive deficits by modulating hippocampal inflammation and neurogenesis: A comprehensive study integrating Mendelian randomization. Experimental neurology, 396, 115543.
[5] Zhu, S., Ding, X., Bo, J., Shi, W., Xia, T.,* & Gu, X. (2025). Brain network connectivity and dementia risk: a bidirectional Mendelian randomisation perspective. NeuroImage. Clinical, 48, 103913.
[6] Ding, X., Zheng, Z., Wang, H., Shao, Y., Zhu, S., Ma, Z., Gu, X., Xia, T.,* & Alzheimer's Disease Neuroimaging Initiative (2025). Persistent depressive-symptom trajectories predict conversion from mild cognitive impairment to Alzheimer's disease: A longitudinal ADNI study. Journal of affective disorders, 391, 120066.
[7] Wang, Z., Dong, R., Han, Y., Peng, L., Liu, S., Ma, Z., Xia, T.,* & Gu, X. (2025). ω-3 PUFAs Alleviate GJ-Cx43 Uncoupling Induced by Long-Term Isoflurane Exposure by Activating the Wnt/β-catenin Signaling Pathway in Astrocytes. Cell biology international, 49(7), 865–877.
[8] Zhu, S., Bo, J., Xia, T.,* & Gu, X. (2025). Temporal patterns of cognitive decline after hypertension onset among middle-aged and older adults in China. Scientific reports, 15(1), 16300.
[9] Cui, Y., Zheng, Z., Zhou, Q., Han, X., Liu, S., Xia, T.,* Gu, X., & Zhang, Y. (2025). The role of clock control of DRP1 activity involved in postoperative cognitive dysfunction. Experimental neurology, 385, 115140.
[10] Zhou, J., Han, X., Wei, Z., Liu, Y., Xu, J., Xu, M., Xia, T.,* Cheng, X., & Gu, X. (2025). Deciphering the CREB-NR2B axis: Unraveling the crosstalk of insulin and TGF-β signalling in ameliorating postoperative cognitive dysfunction. Life sciences, 370, 123574.
[11] Xie, W., Xi, Y., Dong, D., Liu, S., Ma, Z., Peng, L., Xia, T.,* & Gu, X. (2024). LanCL1 protects developing neurons from long-term isoflurane anesthesia-induced neurotoxicity. Experimental neurology, 381, 114880.
[12] Liu, Y., Han, X., Su, Y., Zhou, Y., Xu, M., Xu, J., Ma, Z., Gu, X., & Xia, T.* (2025). Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice. Neural regeneration research, 20(9), 2727–2736.
[13] Dong, R., Han, Y., Lv, P., Jiang, L., Wang, Z., Peng, L., Liu, S., Ma, Z., Xia, T.,* Zhang, B., & Gu, X. (2024). Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 44(8), 1450–1466.
[14] Dong, R., Lv, P., Han, Y., Jiang, L., Wang, Z., Peng, L., Ma, Z., Xia, T.,* Zhang, B., & Gu, X. (2022). Enhancement of astrocytic gap junctions Connexin43 coupling can improve long-term isoflurane anesthesia-mediated brain network abnormalities and cognitive impairment. CNS neuroscience & therapeutics, 28(12), 2281–2297.
[15]Peng, L., Liu, S., Xu, J., Xie, W., Fang, X., Xia, T.,* & Gu, X. (2022). Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice. International immunopharmacology, 109, 108903.
