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刘原
教授
研究领域
肿瘤免疫治疗
yuanliu@nju.edu.cn

工作经历

荣誉奖励

学术任职

代表性成果

1. Liang H, Lu G, Bian Z, Qu S, Shi L, Wang J, Zen K, Liu Y*. SIRPα extracellular domain shed from neutrophils by ADAM10 aggravates sepsis via initiating nitric oxide release from erythrocyte. J Adv Res. 2025 Aug 17:S2090-1232(25)00608-3.


2. Bian Z, Shi L, Kidder K, Zen K, Garnett-Benson C, Liu Y*. Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy. Nat Commun. 2021 May 28;12(1):3229.


3. Shi L, Kidder K, Bian Z, Chiang SKT, Ouellette C, Liu Y*. SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages. Sci Signal. 2021;14(702):eabb3966.


4. Shi L, Bian Z, Kidder K, Liang H, Liu Y*. Non-Lyn src family kinases activate SIRPα–SHP-1 to inhibit PI3K–Akt2 and dampen proinflammatory macrophage polarization. J Immunol. 2021;207(5):1419-27.


5. Bian Z, Abdelaal AM, Shi L, Liang H, Xiong L, Kidder K, Venkataramani M, Culpepper C, Zen K, Liu Y*. Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation. Eur J Immunol. 2018 Feb 28.


6. Bian Z, Shi L, Venkataramani M, Abdelaal AM, Culpepper C, Kidder K, Liang H, Zen K, Liu Y*. Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice. Eur J Immunol. 2018 Mar;48(3):532-542.


7. Kidder K, Bian Z, Shi L, Liu Y*. Inflammation unrestrained by SIRPα induces secondary hemophagocytic lymphohistiocytosis independent of IFN-γ. J Immunol. 2020;205(10):2821-33.


8. Niu S, Paluszynski J, Bian Z, Shi L, Kidder K, Liu Y*. LPS-primed CD11b+ leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice. Sci Rep. 2018;8(1):3994.


9. Zhu, D., C. Pan, J. Sheng, H. Liang, Z. Bian, Y. Liu*, P. Trang, J. Wu, F. Liu, C.-Y. Zhang and K. Zen Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol. 2018;3(4): 503-513.


10. Wei, Y., D. Wang, F. Jin, Z. Bian, L. Li, H. Liang, M. Li, L. Shi, C. Pan, D. Zhu, X. Chen, G. Hu, Y. Liu*, C.-Y. Zhang and K. Zen Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nat Commun. 2017; 8(1): 14041.