工作经历
荣誉奖励
学术任职
代表性成果
1.Aggarwal V*, Liu C*, Cui J, Wang HG, Manne S, Vignali KM, Wherry EJ, Workman CJ, Vignali, DAA, Tumor-specific stem-like progenitor exhausted CD8+ T cell subsets diverge into terminally exhausted cells and long-lived memory T cells. Under revision at Journal of Experimental Medicine (* Equal contribution)
2.Andrews LP, Cardello C, Cui J, Liu C, Brunazzi EA, Shin Foong Ngiow, Huang YH, Manne S, Sharpe AH, Wherry EJ, Workman CJ, Vignali DAA, PD1 and LAG3 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFNγ-dependent anti-tumor immunity. Cell 2024, 187, 4355-4372
3.Liu C, Somasundaram A, Manne S, Gocher AM, Szymczak-Workman AL, Vignali KM, Normolle DP, Ferris RL, Bruno TC, Wherry EJ, Workman CJ, Vignali DAA, Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity. Nat. Immunol. 2020, 21, 1010–1021
4.Chuckran CA*, Liu C*, Bruno TC, Workman CJ, Vignali DAA, Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy. Journal for ImmunoTherapy of Cancer 2020, 8: e000967 * Equal contribution)
5.Liu C, Chikina M, Deshpande R, Menk, AV, Wang T, Tabib T, Brunazzi, EA, Vignali KM, Sun M, Stolz DB, Lafyatis RA, Chen W, Delgoffe GM, Workman CJ, Wendell SG, and Vignali, DA, Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+ T cell-derived Interferon-γ. Immunity 2019, 51 (2), 381-397.e6
6.Liu C, Workman CJ, Vignali DAA. Targeting Regulatory T Cells in Tumors. FEBS J. 2016, 283 2731-48
7.Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ , Kirkwood JM , Lipson EJ, Ferris RL, Bruno TC , Workman CJ and Vignali DAA, Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Sci. Immunol. 2020, 5 (49), eabc2728
8.Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA, Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Nat. Immunol. 2019 20, 724–735