工作经历
2023 - 至今南京大学医学院附属鼓楼医院 神经内科副主任
2012– 至今南京大学医学院附属鼓楼医院住院医师-主治医师-副主任医师-主任医师
荣誉奖励
1. 2025，缺血性脑损伤的新机制以及转化研究，江苏医学科技奖一等奖（第三完成人）
2. 2022，缺血性脑损伤新机制及其临床干预策略，华夏医学科技奖二等奖（第二完成人）
3. 2021，结构-功能多尺度海马环路特征及干预靶点在AD中的基础和临床研究，江苏医学科技奖一等奖（第二完成人）
4. 2020，免疫炎症与缺血性卒中转归的机制及临床转化研究，中华医学科技奖三等奖（第三完成人）
5. 2020，缺血性脑损伤免疫炎症机制以及临床转化研究，江苏医学科技奖一等奖（第三完成人）
学术任职
2019-，《Neuroscience Bulletin》 青年编委
代表性成果
1. Mao R#, Shu S#, Sun M#, Chen J, Hu M, Ye L, Xu S, Jia J, Shao W, Bao X, Xu Y*, Zhu X*. Edaravone-Dexborneol slows down pathological progression and cognitive decline via inhibiting S100A9 in APPswe/PS1dE9 mice. Alzheimers Res Ther. 2025;17(1):139.
2. Huang L#, Li Z#, Zhu X#, Zhao H, Mao C, Ke Z, Mo Y, Yang D, Cheng Y, Qin R, Hu Z, Shao P, Chen Y, Lou M*, He K*, Xu Y*. Deep adaptive learning predicts and diagnoses CSVD-related cognitive decline using radiomics from T2-FLAIR: a multi-centre study. NPJ Digit Med. 2025;8(1):444.
3. Jia B, Xu Y, Zhu X*. Cognitive resilience in Alzheimer's disease: Mechanism and potential clinical intervention. Ageing Res Rev. 2025; 106: 102711.
4. Wang S#, Huang J#, Chen Y, Liang Y, Chen L, Ye D, Yang H, Hui Z, Wang X, Zhang Z*, Zhu X*. Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice. J Ethnopharmacol. 2024; 333: 118497.
5. Qu L#, Fang S#, Lan Z, Xu S, Jiang J, Pan Y, Xu Y, Zhu X*, Jin J*. Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS. Cardiovasc Diabetol. 2024; 23(1): 215.
6. Chen J#, Zhang Z#, Liu Y, Huang L, Liu Y, Yang D, Bao X, Liu P, Ge Y, Li Q, Shu X, Xu L, Shi YS, Zhu X*, Xu Y*. Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline. Alzheimers Dement. 2024; 20: 3504–3524.
7. Xue Z#, Ye L#, Ge J#, Lan Z#, Zou X, Mao C, Bao X, Yu L, Xu Y, Zhu X*. Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice. Pharmacol Res. 2023; 194: 106864.
8. Ge J#, Xue Z#, Shu S#, Yu L, Qin R, Tao W, Liu P, Dong X, Lan Z, Bao X, Ye L, Xu Y, Zhu X*. MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice. JCI Insight. 2023;8(12):e166270.
9. Ye L#, Shu S#, Jia J, Sun M, Xu S, Bao X, Bian H, Liu Y, Zhang M, Zhu X*, Bai F*, Xu Y*. Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis. Aging Cell. 2023; 22(7):e13860.
10. Tao W#, Yu L#, Shu S#, Liu Y, Zhuang Z, Xu S, Bao X, Gu Y, Cai F, Song W, Xu Y*, Zhu X*. miR-204-3p/Nox4 Mediates Memory Deficits in a Mouse Model of Alzheimer's Disease. Mol Ther. 2021, 29(1):396-408.
