工作经历
2011年博士于中科院上海生物化学与细胞生物学研究所，师从裴钢院士。2013年加入国际知名T细胞生物学家 Dr. Dario A. A. Vignali 教授实验室，先后任 Postdoctoral Associate (2013～2014) ，Research Associate (2014~2019) 和 Research Scientist (2019~2021) 。2022年入职南京大学现代生物研究院
荣誉奖励
2018年获美国肿瘤免疫治疗协会（SITC, Society of Immunotherapy for Cancer）Young Investigator Award
学术任职
Immunity, Journal for ImmunoTherapy of Cancer 及 Frontier Immunol. 审稿人
代表性成果
1. Andrews LP, Cardello C, Cui J, Liu C, Brunazzi EA, Shin Foong Ngiow, Huang YH, Manne S, Sharpe AH, Wherry EJ, Workman CJ, Vignali DAA, PD1 and LAG3 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFNγ-dependent anti-tumor immunity. Cell 187, 4355-4372 (2024)
2. Liu C, Somasundaram A, Manne S, Gocher AM, Szymczak-Workman AL, Vignali KM, Normolle DP, Ferris RL, Bruno TC, Wherry EJ, Workman CJ, Vignali DAA, Neuropilin-1 is a T cell memory checkpoint limiting long-term anti-tumor immunity. Nat. Immunol. 21, 1010–1021 (2020) (Highlighted in News and Views, Nat. Immunol. 21, 972–973（2020)
3. Chuckran CA*, Liu C*, Bruno TC, Workman CJ, Vignali DAA. Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy. Journal for ImmunoTherapy of Cancer 2020;8: e000967 * Equal contribution). Review
4.Liu C, Chikina M, Deshpande R, Menk, AV, Wang T, Tabib T, Brunazzi, EA, Vignali KM, Sun M, Stolz DB, Lafyatis RA, Chen W, Delgoffe GM, Workman CJ, Wendell SG, and Vignali, DA. Treg cells promote the SREBP1-dependent metabolic fitness of tumor-promoting macrophages via repression of CD8+ T cell-derived Interferon-γ. Immunity, 51 (2), 381-397.e6 (2019)
5. Andrews, LP., Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ , Kirkwood JM , Lipson EJ, Ferris RL, Bruno TC , Workman CJ and Vignali DAA. Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Sci. Immunol. 5 (49), eabc2728 (2020)
6. Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA. Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion. Nat. Immunol. 20, 724–735 (2019)
7. Liu C, Workman CJ, Vignali DA. Targeting Regulatory T Cells in Tumors. FEBS J. 283(14): 2731-48 (2016) Review
8. Zhang Y, Liu C, Wei B, Pei G, Loss of b-arrestin2 exacerbates experimental autoimmune encephalomyelitis with reduced number of Foxp3+CD4+ regulatory T cells. Immunology 140: 430-440 (2013)
9. Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G. Deficiency of b-arrestin1 ameliorates collagen-induced arthritis with impaired TH17cell differentiation. Proc Natl Acad Sci U S A. 110: 7395-400 (2013)
10. Du C*, Liu C*, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 10:1252-9 (2009). (*Equal contribution)
11. Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C. Improvement of morphine-mediated analgesia by inhibition of b-arrestin 2 expression in mice periaqueductal gray matter. Int J Mol Sci. 10:954-63 (2009).
12. Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G. Critical regulation of CD4+ T cell survival and autoimmunity by b-arrestin 1. Nat Immunol. 8:817-24 (2007).
