工作经历
2017年毕业于中国科学院上海生物化学与细胞生物学研究所，获得生物化学与分子生物学博士学位。2021年前往美国St. Jude儿童研究医院继续博士后研究，专注于肿瘤细胞的免疫逃逸机制研究以及肿瘤免疫治疗靶点的鉴定。2025年加入南京大学现代生物研究院，担任准聘(Tenure-Track) 助理教授，研究员，博士生导师。
荣誉奖励
学术任职
代表性成果
1. Sujing Yuan*, Renqiang Sun*, Hao Shi, Nicole M. Chapman, Haoran Hu, Cliff Guy, Sherri Rankin, Anil KC, Gustavo Palacios, Xiaoxi Meng, Xiang Sun, Peipei Zhou, Xiaoyang Yang, Stephen Gottschalk, Hongbo Chi. (2025) VDAC2 loss unleashes tumor destruction and inflammation for cancer therapy. Nature. 640 (8060) 1062-1071.
2. Erienne G. Norton, Nicole M. Chapman, Hao Shi, Xiaoxi Meng, Hongling Huang, Anil KC, Sherri Rankin, Jordy Saravia, Sujing Yuan, Haoran Hu, Peter Vogel, Hongbo Chi. (2025) Vps34-orchestrated lipid signaling processes regulate the transitional heterogeneity and functional adaptation of effector regulatory T cells. Plos Biology. Apr 11; 23(4): e3003074.
3. Peipei Zhou*, Hao Shi*, Hongling Huang*, Xiang Sun, Sujing Yuan, Nicole M. Chapman, Jon P. Connelly, Seon Ah Lim, Jordy Saravia, Anil KC, Shondra M. Pruett-Miller, Hongbo Chi. (2023) Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer. Nature. 624 (7990), 154-163.
4. Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi. (2023) SLC38A2 and glutamine signaling in cDC1s dictate anti-tumor immunity. Nature. 620 (7972), 200-208.
5. Sujing Yuan, Hongbo Chi. (2023) Early immune pressure makes tumors metabolically stronger. Cell Metabolism. 35 (1), 3-5.
6. Ao Guo*, Hongling Huang*, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green. (2022) cBAF complex components and MYC cooperate early in CD8+ T cell fate. Nature. 607 (7917), 135-141.
7. Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen. (2022) Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer. EMO molecular Medicine. 14 (1), e14502.
8. Xiao Hu, Yanli Zou, David A Copland, Lauren P Schewitz-Bowers, Yan Li, Philippa JP Lait, Madeleine Stimpson, Zhihui Zhang, Shixin Guo, Juanran Liang, Tingting Chen, Jing Jing Li, Sujing Yuan, Shuo Li, Penghui Zhou, Yizhi Liu, Andrew D Dick, Xiaofeng Wen, Richard WJ Lee, Lai Wei. (2022) Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. Ebiomedicine. 86.
9. Lingyi Fu*, Sen Li*, Weiwei Xiao*, Kuai Yu, Shuo Li, Sujing Yuan, Jianfei Shen, Xingjun Dong, Ziqian Fang, Jianeng Zhang, Siyu Chen, Wende Li, Hua You, Xiaojun Xia, Tiebang Kang, Jing Tan, Gong Chen, An-Kui Yang, YuanHong Gao, Penghui Zhou. (2021) DGKA Mediates Resistance to PD-1 Blockade. Cancer Immunology Research. 9 (4), 371-385.
10. Sujing Yuan, Yu Wu, Yigang Wang, Jianhua Chen, Liang Chu. (2017) An oncolytic adenovirus expressing SNORD44 and GAS5 exhibits anti-tumor effect in colorectal cancer cells. Human Gene Therapy. 28 (8), 690-700.
11. Kangjian zhang*, Xiaofei Yin*, Yuanqin Yang*, Huiling Li, Yanni Xu, Lieyang Chen, Xijun Liu, Sujing Yuan, Xianlong Fang, Jing Xiao, Shuai Wu, Haineng Xu, Liang Chu, Kanstantsin V. Katlinski, Yuliya V Katlinskaya, Rongbing Guo, Guangwen Wei, Dacheng Wang, Xin-Yuan Liu, Serge Y Fuchs. (2017) A potent in vivo anti-tumor efficacy of novel recombinant type I interferon. Clinical Cancer Research. 23 (8), 2038-2049.
12. Yanni Xu, Liang Chu, Sujing Yuan, Yuanqin Yang, Yu Yang, Bin Xu, Kangjian Zhang, Xin-Yuan Liu, Zhinan Chen, Zongsuo Liang. (2017) RGD-modified oncolytic adenovirus-mediated PKM2 knockdown exhibits potent cytotoxic effect in pancreatic cancer. Cell Death and Disease. 8 (6), e2835-e2835.
13. Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun, Xin-Yuan Liu, Yourong Duan. (2016) Systemic Administration of Stabilized Lipids/Calcium Phosphate- oncolytic Adenovirus Complexes for Cancer Gene Therapy. ACS Nano. 10 (12), 11548-11560.
14. Sujing Yuan, Xianlong Fang, Yanni Xu, Aimin Ni, Xin-Yuan Liu, Liang Chu. (2016) An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells. Oncotarget. 7(37):60491.
15. Chunwei Lv; Qunshu Su; Yupei Liang; Jinqing Hu; Sujing Yuan. (2016) Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis. Biochemical and Biophysical Research Communications. 476 (1), 21-28.
