1990年在美国阿拉巴马州立大学伯明翰分校(UAB)获博士学位。

1991年在美国加州大学圣地亚哥分校(UCSD)从事博士后研究。

1996年在美国阿拉巴马州立大学伯明翰分校任准聘助理教授；

1999年在美国芝加哥大学任准聘助理教授，2002年晋升为终身副教授，2006年晋升为终身正教授；

2009年中科院上海生化与细胞所所长，课题组长，博士生导师，终身正教授, 国家特聘教授；

2014年芝加哥大学任终身正教授；

2020年任南京大学现代生物研究院创院院长，独立学科带头人，博士生导师，终身正教授，国家特聘教授，南京大学医学院附属鼓楼医院特聘教授。

Molecular and Cellular Biology编委

Cell Research编委

1. Zhang, W., Zhangyuan, Y., Wang, F., Jin, K., Shen, H., Zhang, L., Yuan, X., Wang, J., Zhang, H., Yu, W., Huang, R., Xu, X., Yin, Y., Zhong, G., Lin, A*., Sun, B*. (2021). The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation. Immunity. 

2. Zhang, L., Qian, Y., Li, J., Zhou, X., Xu, H., Yan, J., Xiang, J., Yuan, X., Sun, B., Sisodia, S., Jiang, Y., Cao, X., Jing, N., Lin, A*. (2021). BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience. 

3. Li, J., Zhang L., Zheng, Y., Shao, R., Liang, Q., Yu W., Wang, H., Zou, W., Wang, D., Xiang, J., Lin, A*.(2020). BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. eLife 9: e56309.

4. Yan, J., Zhang, H., Xiang, J., Zhao, Y., Yuan, X., Sun, B., and Lin, A*. (2018). The BH3-only protein BAD mediates TNFalpha cytotoxicity despite concurrent activation of IKK and NF-kappaB in septic shock. Cell Res 28, 701-718.

5. Yan, J., Xiang, J., Lin, Y., Ma, J., Zhang, J., Zhang, H., Sun, J., Danial, N.N., Liu, J., and Lin, A*. (2013). Inactivation of BAD by IKK inhibits TNFalpha-induced apoptosis independently of NF-kappaB activation. Cell 152, 304-315.

6. Liu, J., Yan, J., Jiang, S., Wen, J., Chen, L., Zhao, Y., and Lin, A*. (2012). Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-alpha-induced JNK activation and inflammation. Proc Natl Acad Sci 109, 191-196.

7. Liu, J., Zhao, Y., Eilers, M., and Lin, A*. (2009). Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proc Natl Acad Sci 106, 18279-18284.

8. Liu, J., Yang, D., Minemoto, Y., Leitges, M., Rosner, M.R., and Lin, A*. (2006). NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 21, 467-480.

9. Yu, C., Minemoto, Y., Zhang, J., Liu, J., Tang, F., Bui, T.N., Xiang, J., and Lin, A*. (2004). JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13, 329-340.

10. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., and Lin, A*. (2001). Inhibition of JNK activation through NF-kappaB target genes. Nature 414, 313-317.

- (2001). News and Views, Nature414, 265-266.

- (2001). Highlights, Nature Reviews2, 875.

- (2003). Hot Papers, The Scientist12,32-33.

11. Tang, G., Yang, J., Minemoto, Y., and Lin, A*. (2001). Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. Mol Cell 8, 1005-1016.

12. Purcell, N.H., Tang, G., Yu, C., Mercurio, F., DiDonato, J.A., and Lin, A*.(2001). Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci 98, 6668-6673.

13. Minden, A., Lin, A., Claret, F.X., Abo, A., and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.

14. Lin, A., Minden, A., Martinetto, H., Claret, F.X., Lange-Carter, C., Mercurio, F., Johnson, G.L., and Karin, M. (1995). Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268, 286-290.

15. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Derijard, B., Davis, R.J., Johnson, G.L., and Karin, M. (1994). Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-1723.