工作经历
2024-05至今，南京大学，特聘研究员
荣誉奖励
学术任职
2025-, 《ExRNA》青年编委
2020-, 南京大学-片仔癀中药小RNA功能与应用研究联合中心副主任
代表性成果
[1]Hu X*, Geng Y*, Shen L*, Tao C, Wang F, Guo H#, Chen X#, Chen Y#, Fu Z#. SFTSV-encoded microRNA-like small RNA as prognostic biomarkers in severe fever with thrombocytopenia syndrome. Emerg Microbes Infect. 2026 Dec;15(1):2608405.
[2]Lei J*, Dong Y*, Wu Y*, Zhang CY#, Fu Z#. Extracellular RNA dimension in alternative medicine: processing–dependent integrity and bioactivity of honeysuckle miRNA MIR2911. Signal Transduction and Targeted Therapy. 2026;11(1):257.
[3]Sun Y, Zhao Y, Yang Y, Li Z, Bai M, Sheng Q, Fu Z, Yan S, Wang Q, Tu W. Targeted KRAS suppression in colorectal cancer via in vivo self-assembled siRNAs encapsulated in endogenous small extracellular vesicles. Journal of Controlled Release. 2026;115256.
[4]Fu Z*, Li L, Wang Y, Yin X, Chen X, Yan C#, Li D#, Zhang CY#. RNA immunity: an ancient defense mechanism preserved in mammalian cells. Science bulletin. 2026;71(1):18-22.
[5]Guo H*, Zhang X*, Bai X*, Su Y, Yuan R, Guo X, Zhou Z, Hu X, Yan C#, Chen X#, Zhang CY#, Fu Z# IVSA-based siRNA targeted delivery system as a universal strategy for the treatment of EGFR-positive cancer. Science China Life Sciences. 2026;46041.
[6]Javed A*, Ur-Rehman U*, Yuan R, Chen X#, Guo H#, Fu Z#. In vivo genetic circuit drives systemic PARP1 siRNA assembly into small extracellular vesicles for BRCA2-deficient breast cancer therapy. Journal of Controlled Release. 2026;114973.
[7]Li Y, Liu Y, Guo H#, Fu Z#. RNA modifications in mammals: from basic research to biotechnological application. ExRNA. 2025;7(1):25-26.
[8]Lin HY*, Li GY*, Liang WL, Wang Y, Fu BY, Du QG, Zhang YT, Xu ZK, Cui H, Chen X, Fu Z#, Zhang JG#. MiR-301a-3p Promotes Triple-Negative Breast Cancer Progression via PTEN Suppression in Tumor Cells and the Microenvironment. World Journal of Oncology. 2025;16(6):645.
[9]Sun Y*, Zhao Y*, Ni X*, Yang Y*, Fu Z#, Liu R#, Zhang CY#, Chen X#. In vivo self- assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer. J Control Release. 2023 Jun;358:142-160.
[10]Guo X*, Guo H*, Lu KC*, Yan X*, Chen J, Wei Y, Han J, Sun W, Hu H, Su Y, Shen L, Zhang Y#, Yin K#, Zhang CY#, Fu Z#. Identification of 3'-terminal 2'-O-methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC. Clin Transl Med. 2023 Nov;13(11):e1454.
[11]Kong Y, Hu H, Shan Y, Zhou Z, Zen K, Sun Y, Yang R#, Fu Z#, Chen X#. Accurate quantification of 3'-terminal 2'-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR. Front Med. 2022 Apr;16(2):240-250. doi: 10.1007/s11684-021-0909-7. Epub 2022 Apr 13. PMID: 35416629.
[12]Fu Z*, Zhang X*, Zhou X*, Ur-Rehman U*, Yu M*, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu SF, Wu D, Zen K, Li J#, Yan C#, Zhang CY#, Chen X#. In vivo self-assembled small RNAs as a new generation of RNAi therapeutics. Cell Res. 2021 Jun;31(6):631-648.
[13]Fu Z*, Wang J*, Wang Z*, Sun Y*, Wu J, Zhang Y, Liu X, Zhou Z, Zhou L, Zhang CY, Yi Y#, Xia X#, Wang L#, Chen X#. A virus-derived microRNA-like small RNA serves as a serum biomarker to prioritize the COVID-19 patients at high risk of developing severe disease. Cell Discov. 2021 Jul 6;7(1):48.
[14]Wang Y*, Zhu X*, Jiang XM*, Guo J*, Fu Z*, Zhou Z*, Yang P, Guo H, Guo X, Liang G, Zeng P, Xiao G, Ma J, Yin X, Zhang LK#, Yan C#, Zhang CY#. Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients. Signal Transduct Target Ther. 2021 Aug 11;6(1):300. doi: 10.1038/s41392-021-00716-y. PMID: 34381015; PMCID: PMC8355568.
[15]Li X*, Fu Z*, Liang H*, Wang Y*, Qi X*, Ding M, Sun X, Zhou Z, Huang Y, Gu H, Li L, Chen X, Li D, Zhao Q, Liu F, Wang H, Wang J#, Zen K#, Zhang CY#. H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2. Cell Res. 2018 Feb;28(2):157-171. doi: 10.1038/cr.2018.3. Epub 2018 Jan 12. PMID: 29327729; PMCID: PMC5799819.
